Publication

† denoted as equal contribution as first author ;  * denoted as corresponding author 

  1. Das, C. M.; Yang, F.; Yang, Z.; Liu, X.; Hoang, Q. T.; Xu, Z.; Neermunda, S.; Kong, K. V.;* Ho, H.-P.; Ju, L. A.; Xiong, J.;* Yong, K.-T.* Computational Modeling for Intelligent Surface Plasmon Resonance Sensor Design and Experimental Schemes for Real-Time Plasmonic Biosensing: A Review.  Advanced Theory and Simulations 2023, 6 (9), 2200886.

  2. Savunthari, K. V.; Balaji, D.; Sudheer, N.; Bathwar, M.; Rangasamy, M.; Dhandabani, G. K.; Puente Santiago, A. R.; Shanmugam, S.; Kong, K.-V.;* Vijayaraghavan, R.,* Effective photocatalytic degradation of rhodamine-B over Zn-doped BaO2 and SrO2 composites under UV and sunlight irradiation. RSC Sustainability 2023, 1 (6), 1511-1521.

  3. Shuyun, W.; Lin, F.; Pan, C.; Zhang, Q.; Tao, H.; Fan, M.; Xu, L.; Kong, K. V.; Chen, Y.; Lin, D.;* Feng, S.,* Laser tweezer Raman spectroscopy combined with deep neural networks for identification of liver cancer cells. Talanta 2023, 264, 124753.

  4. Wu, Cheng-Yun ; Chen, Hsin-Jou ; Wu, Yun-Chin ; Tsai, Shu-Wei ; Liu, Yi-Hung; Bhattacharya, Ushashi ; Lin, Duo; Tai, Hwan-Ching ; Kong, Kien Voon*. Highly Efficient Singlet Oxygen Generation by BODIPY-Ruthenium(II) Complexes for Promoting Neurite Outgrowth and Suppressing Tau Protein Aggregation. Inorg. Chem. 2023, 62, 3, 1102-1112.  (selected as Cover)

  5. Soon Poh Lee; Gomaa A.M. Ali; Mohammed A. Assiri; Kien Voon Kong; Ellie Yi Lih Teo; Kwok Feng Chong* Pseudocapacitive performance of phenothiazine functionalized graphene aerogel. Appl. Surf. Sci. 2023, 613, 156069.

  6. Nur Amira Solehah Pungut, Chun Hoe Tan, Hazwani Mat Saad, Kae Shin Sim, Sheena Yin Xing Tiong, Chee Wei Ang, Chun Hau Gan, Kien Voon Kong, Kong Wai Tan*. A new cinnamaldehyde-rhodamine based dual chemosensor for Cu2+ and Fe3+ and its applicability in live cell imaging. J. Photochem. Photobiol. A.  2023, 438, 114540.

  7. Li Jiang, Kien Voon Kong*, Sailing He, Ken-Tye Yong* Plasmonic Biosensing with Nano-Engineered Van der Waals Interfaces. ChemPlusChem 2022, 87, e202200221.

  8. Tingyin Wang, Youzhi Zhu, Shuyun Weng, Xueliang Lin, Kien Voon Kong, Youliang Weng, Xianggang Jia, Rong Chen, Duo Lin, and Shangyuan Feng Optical biosensor based on SERS with signal calibration function for quantitative detection of carcinoembryonic antigen. Biomedical Optics Express 2022, 13, 5962-5970

  9. Yun-Chin Wu†, Cheng-Yun Wu†, Shu-Wei Tsai, Hsin-Jou Chen, Wang-Jing Liu, Duo Lin, Tianxun Gong, Ken-Tye Yong, Kien Voon Kong* Merocyanine Complexes Coupled with Plasmonic Au Nanoparticles for Inhibiting Tau Aggregation ACS Applied Nano Materials 2022, 5 (12), 17613-17621 (selected as Cover) 

  10. Jinyong Lin, Youliang Weng, Xueliang Lin, Sufang Qiu, Zufang Huang, Changbin Pan, Ying Li, Kien Voon Kong, Xianzeng Zhang*, Shangyuan Feng* Highly Efficient Blood Protein Analysis Using Membrane Purification Technique and Super-Hydrophobic SERS Platform for Precise Screening and Staging of Nasopharyngeal Carcinoma. Nanomaterials 2022, 12(15), 2724

  11. Ying-Feng Hsu, Ting-Wei Wu, Yu-Hsuan Kang, Cheng-Yun Wu, Yi-Hung Liu, Shie-Ming Peng, Kien Voon Kong*, Jye-Shane Yang* Porous Supramolecular Assembly of Pentiptycene-Containing Gold(I) Complexes: Persistent Excited-State Aurophilicity and Inclusion-Induced Emission Enhancement. Inorg. Chem. 2022, 61, 30, 11981-11991

  12. Chandreyee Manas Das, Kien Voon Kong, Ken-Tye Yong* Diagnostic plasmonic sensors: opportunities and challenges. Chem. Commun., 2022,58, 9573-9585

  13. Yun-Chin Wu, Yu-Chiao Liu, Shu-Wei Tsai, Kai-Ti Chu, Hsin-Jou Chen, Cheng-Yun Wu, Yu-Yi Hsu, Chang-Chih Hsieh, Wang-Jing Liu, Kien Voon Kong,* Ming-Hsi Chiang* Demethylation of Artificial Hydrogenase Agent for Prolonged CO Release and Enhanced Anti-Tau Aggregation Activity; Chem. Comm.; 2022,58, 7245-7248 (selected as Cover)

  14. Duo Lin†, Chang-Lin Hsieh†, Keng-Jia Hsu, Pei-Hsuan Liao, Sufang Qiu, Tianxun Gong, Ken-Tye Yong, Shangyuan Feng, and Kien Voon Kong*. Geometrically Encoded SERS Nanobarcodes for the Logical Detection of Nasopharyngeal Carcinoma-related Progression Biomarkers; Nature Commun.; 12 (1), 1-16

  15. Duo Lin , Shang-Wei Yang , Chang-Lin Hsieh , Keng-Jia Hsu, Tianxun Gong, Qiong Wu, Sufang Qiu*, Shangyuan Feng*, and Kien Voon Kong*. Tandem Quantification of Multiple Carbohydrates in Saliva Using Surface-Enhanced Raman Spectroscopy; ACS Sensors; 2021,  6 (3), 1240-1247

  16. Keng-Jia Hsu† , Chang-Lin Hsieh† , Chi-Jui Tsai, Kien Voon Kong*. Probing Molecular-Scale Oxidative Generation of Quinone Methides and Their Transformation Using Tip-Enhanced Raman Spectroscopy;     The Journal of Physical Chemistry Letters; 2021, 12, 3, 1110-1115. (selected as Cover) 
  17. Zi-Yu Ke, Chi-Jui Tsai, Pei-Hsuan Liao, and Kien Voon Kong*. Photoinduced Enhanced Raman Probe for Use in Highly Specific and Sensitive Imaging for Tyrosine Dimerization in Inflammatory Cells;                             The Journal of Physical Chemistry Letters; 2020, 11, 17, 7443-7448
  18. Cheng-Zong Kuo, Li-Yun Hsu, Yu-Shan Chen, Kenta Goto, Subhendu Maity, Yi-Hung Liu, Shie-Ming Peng, Kien Voon Kong*, Teruo Shinmyozu, Jye-Shane Yang*. Alkyl Chain Length‐and Polymorph‐Dependent photomechanochromic fluorescence of anthracene photodimerization in molecular crystals: roles of the lattice stiffness. Chemistry-A European Journal; 2020, 26, 11511.
  19. Pei-Hsuan Liao, Ching-Yu Tseng, Zi-Yu Ke, Chang-Lin Hsieh, Kien Voon Kong*. Operando characterization of chemical reactions in single living cells using SERS. Chemical Communications; 2020,56, 4852-4855
  20. Yi-Cheng Lin†, Zi-Yu Ke†, Pei-Hsuan Liao, Ching-Yu Tseng and Kien Voon Kong*; Reversible Detection of Phosphorylation and Dephosphorylation by Tip-Enhanced Raman Spectroscopy using Cyclopentadienyl Ruthenium Nanotags Functionalized Tip; Chemical Communications; 2020, 56 (6), 936-939
  21. Yi‐Hsin Chien, Kok Ken Chan, Tommy Anderson, Kien Voon Kong, Beng Koon Ng, Ken‐Tye Yong*. Advanced Near‐Infrared Light‐Responsive Nanomaterials as Therapeutic Platforms for Cancer Therapy. Advanced Therapeutics 2019, 2 (3), 1800090
  22. Duo Lin, Jiahui Zhou, Yun Yu, Weiwei Chen, Pei-Hsuan Liao, Hao Huang*, Kien Voon Kong*, A dual-mode biosensor combining transition metal carbonyl-based SERS and a colorimetric readout for thiol detection. Analytical Methods 2019, 11 (41), 5232-5236
  23. Duo Lin, Tianxun Gong, Sufang Qiu, Qiong Wu, Ching-Yu Tseng, Kien Voon Kong*, Guannan Chen*, Rong Chen* A dual signal amplification nanosensor based on SERS technology for detection of tumor-related DNA. Chemical Communications 2019, 55 (11), 1548-1551. (selected as Cover) 
  24. Duo Lin†, Yi-Cheng Lin†, Shang-Wei Yang, Lan Zhou, Weng Kee Leong, Shang-Yuan Feng*, Kien Voon Kong*, Organometallic-Constructed Tip-Based Dual Chemical Sensing by Tip-Enhanced Raman Spectroscopy for Diabetes Detection. ACS Applied Materials & Interfaces 2018, 10 (49), 41902-41908
  25. Duo Lin, Tianxun Gong, Zi-Yao Hong, Sufang Qiu, Jianji Pan, Chinh-Yu Tseng, Shangyuan Feng*, Rong Chen*, Kien Voon Kong* Metal carbonyls for the biointerference-free ratiometric surface-enhanced raman spectroscopy-based assay for cell-free circulating DNA of epstein-barr virus in blood. Analytical Chemistry 2018, 90 (12), 7139-7147
  26. Mein Jin Tan, Han‐Chi Pan, Hui Ru Tan, Jian Wei Chai, Qi Feng Lim, Ten It Wong, Xiaodong Zhou, Zi‐Yao Hong, Lun‐De Liao*, Kien Voon Kong*, Flexible Modulation of CO‐Release Using Various Nuclearity of Metal Carbonyl Clusters on Graphene Oxide for Stroke Remediation. Advanced Healthcare Materials 2018, 7 (5), 1701113. (selected as Cover)  
  27. Duo Lin†, Chinh-Yu Tseng†, Qi Feng Lim, Mein Jin Tan*, Kien Voon Kong*. A rapid and highly sensitive strain-effect graphene-based bio-sensor for the detection of stroke and cancer bio-markers. Journal of Materials Chemistry B 2018, 6, 2536-2540
  28. Yi-Hsin Chien, Chang-Han Wang, Chi-Ching Liu, Shih-Hui Chang, Kien Voon Kong, Yun-Chorng Chang*. Large-Scale Nanofabrication of Designed Nanostructures Using Angled Nanospherical-Lens Lithography for Surface Enhanced Infrared Absorption Spectroscopy. ACS Applied Materials & Interfaces, 2017, 9 , 24917-24925.
  29. Mein Jin Tan†, Zi-Yao Hong†, Mei-Hua Chang, Chih-Chen Liu, Hwei-Fang Cheng, Xian Jun Loh, Ching-Hsiang Chen, Chia-Ding Liao*, Kien Voon Kong*. Metal carbonyl-gold nanoparticle conjugates for highly sensitive SERS detection of organophosphorus pesticides. Biosensors and Bioelectronics, 2017, 96, 167-172.
  30. Tianxun Gong†, Zi-Yao Hong†, Ching-Hsiang Chen, Cheng-Yen Tsai, Lun-De Liao, and Kien Voon Kong*. Optical Interference-Free Surface- Enhanced Raman Scattering CO-Nanotags for Logical Multiplex Detection of Vascular Disease-Related Biomarkers. ACS Nano, 2017, 11 (3), 3365-3375.
  31. Yun-Jui He, Tsung-Han Tu, Ming-Kun Su, Chia-Wei Yang, Kien Voon Kong, and Yi-Tsu Chan*. Facile Construction of Metallo-Supramolecular P3HTb- PEO Diblock Copolymers via Complementary Coordination and Their Self- Assembled Nanostructures. Journal of the American Chemical Society, 2017, 139 (11), 4218-4224.. *

Before Joining NTU

  1. Kosuke Takeda, Sandhya Sriram, Xin Hui Derryn Chan, Wee Kiat Ong, Chia Rou Yeo, Betty Tan, Seung-Ah Lee, Kien Voon Kong, Shawn Hoon, Hongfeng Jiang, Jason J Yuen, Jayakumar Perumal, Madhur Agrawal, Candida Vaz, Jimmy So, Asim Shabbir, William S Blaner, Malini Olivo, Weiping Han, Vivek Tanavde, Sue-Anne Toh, Shigeki Sugii*. Retinoic Acid Mediates Visceral- Specific Adipogenic Defects of Human Adipose-Derived Stem Cells. Diabetes, 2016, 65(5), 1164-1178. 
    ✽ Reported by Medical Xpress
  2. Zhiyong Lam, Ghayathri Balasundaram, Kien Voon Kong, Bo Yang Chor,Douglas Goh, Bahareh Khezri, Richard D Webster, Weng Kee Leong*, Malini Olivo*. High nuclearity carbonyl clusters as near-IR contrast agents for photoacoustic in vivo imaging. Journal of Materials Chemistry B. 2016, 4, 3886-3891. 
    ✽ Published as Advance Article
    ✽ Highlighted by A*STAR Research*
  3. Zhiyong Lam, Kien Voon Kong, Malini Olivo*, Weng Kee Leong*. Vibrational spectroscopy of metal carbonyls for bio-imaging and-sensing. Analyst. 2016,141, 1569-1586.
  4. Tianxun Gong, Nan Zhang, Kien Voon Kong, Douglas Goh, Cui Ying, Jean‐Louis Auguste, Perry Ping Shum, Lei Wei, Georges Humbert, Ken‐Tye Yong, Malini Olivo. Rapid SERS monitoring of lipid‐peroxidation‐derived protein modifications in cells using photonic crystal fiber sensor. Journal of Biophotonics 9, 32-37.
  5. Tianxun Gong+, Kien Voon Kong+, Douglas Goh, Malini Olivo*, Ken-Tye Yong*. Sensitive surface enhanced Raman scattering multiplexed detection of matrix metalloproteinase 2 and 7 cancer markers. Biomedical Optics Express 2015, 6 (6), 2076-2087.  [+ contributed equally]
  6. Tianxun Gong, Ying Cui, Douglas Goh, Kien Voon Kong, Perry Ping Shum, Georges Humbert, Ken-Tye Yong*, Malini Olivo*. "Highly Sensitive SERS Detection and Quantification of Sialic Acid on Single Living Cell Using Photonic-Crystal Fiber with Gold Nanoparticles", Biosensors and Bioelectronics, 2015, 64, 227.
  7. Kien Voon Kong, Douglas Goh, Malini Olivo*, "Dual Trigger Crosslinked Micelles Based Polyamindoamines For Effective Paclitaxel Delivery", Journal of Nanomedicine and Nanotechnology, 2014, 5 (212), 2.
  8. Kien Voon Kong, Lun-de Liao, Douglas Goh, Nitish V. Thakor, Malini Olivo. Novel Biodegradable Nanoparticle Tethered Platinum (II) for Photoacoustic Brain Imaging. Journal of Nanomedicine and Nanotechnology. 5 (223), 2
  9. Kien Voon Kong, Zhiyong Lam, Tianxun Gong, Douglas Goh, Weber Kam On Lau, Weng Kee Leong*, Malini Olivo*. "Rapid and Label-Free SERS Detection of Biomarker In Human Specimen With Metal Carbonyl Functionalized Substrate," Small, 2014, 10 (24), 5030-5034 
    ✽ Selected as Back Cover of Small
    ✽ Highlighted by Singapore NATIONAL RESEARCH FOUNDATION under Scientific Advances
  10. Kien Voon Kong, Lun-de Liao, Zhiyong Lam, Nitish V. Thakor, Weng Kee Leong*, Malini Olivo*, "Organometallic Carbonyl Clusters: A New Class of Contrast Agents for Photoacoustic Cerebral Vascular Imaging," Chemical Communications, 2014, 50, 2601-2603.
  11. Kien Voon Kong+, Jayakumar Perumal+, Reuben M Bakker*, Malini Olivo*. Design and Fabrication of Random Silver Films as substrate for SERS based Nano-Stress sensing of Proteins. RSC Advances, 2014, 4, 12995-13000 
    [+ contributed equally]
  12. Kien Voon Kong, Chris Jun Hui Ho, Tianxun Gong, Weber Kam On Lau, Malini Olivo* "Sensitive SERS-Glucose Sensing in Biological Media Using Alkyne-Functionalized Boronic acid on Planar Substrates," Biosensors and Bioelectronics, 2014, 15, 186-191.
  13. Kien Voon Kong, Dinish U. S, Weber Lau, Malini Olivo*. "Sensitive SERS-pH Sensing in Biological Media Using Metal Carbonyl Functionalized Planar Substrates". Biosensors and Bioelectronics, 2014, 54, 135-140. 
    ✽ Featured Online in Global Medical Discovery
  14. Lun-De Liao, Vassiliy Tsytsarev, Kien Voon Kong, Malini Olivo, Reha S. Erzurumlu and Nitish V. Thakor*, "Progress of the Voltage-Sensitive Dye Imaging in Neuroscience," Journal of Nanoscience and Nanotechnology, 2014, 14, 01-12.
  15. Kien Voon Kong, Zhiyong Lam, Weber Kam On Lau, Weng Kee Leong*, Malini Olivo*, "A Transition Metal Carbonyl Probe for Use in a Highly Specific and Sensitive SERS-based Assay for Glucose," Journal of American Chemical Society, 2013, 135, 18028−18031. *Spotlighted by JACS* *Selected as Front Cover of JACS* *Highlighted by A*STAR research on 09 April 2014*
    ✽ Spotlighted by JACS
    ✽ Selected as Front Cover of JACS
    ✽ Highlighted by A*STAR Research* on 09 April 2014
  16. Stefano Vavassori, Anil Kumar, Gan Siok Wan, Gundimeda S Ramanjaneyulu, Marco Cavallari, Sary El Daker, Travis Beddoe, Alex Theodossis, Neal K Williams, Emma Gostick, David A Price, Dinish U Soudamini, Kien Voon Kong, Malini Olivo, Jamie Rossjohn, Lucia Mori & Gennaro De Libero*. "Butyrophilin 3A1 binds phosphorylated antigens and stimulates human gd T cells", Nature Immunology, 2013, 14, 908-916.  
    ✽ Highlighted by Science Daily
    ✽ Highlighted by A*STAR Research* on 29 January 2014
    ✽ Highlighted by Nano Werk
  17. TianXun Gong, Malini Olivo, U.S. Dinish, Douglas Goh, Kien Voon Kong, K. T. Yong* "Engineering bioconjugated gold nanospheres and gold nanorods as label-free plasmon scattering probes for ultrasensitive multiplex dark-field imaging of cancer cells". Journal of Biomedical Nanotechnology, 2013, 9(6), 985-991.
  18. Kien Voon Kong, Zhiyong Lam, Wenda Douglas Goh, Weng Kee Leong*, Malini Olivo*. "Metal Carbonyl/Gold Nanoparticle Conjugates for Live-Cell SERS Imaging". Angewandte Chemie International Edition. 2012, 51(39), 9796-9. 
    ✽ Selected as HOT paper by Editors of Angewandte Chemie International Edition
  19. Kien Voon Kong; Lim, Lina H. K; Leong, W. K*. Osmium carbonyl cluster induces tubulin polymerisation: Mechanism of action for apoptosis. Chemical Research in Toxicology 2009, 22, 1116-1122. 
    ✽ Highlighted by Cancer Weekly (NewsRX)
  20. Kien Voon Kong; Lim, Lina H. K; Leong, W. K*. Induction of apoptosis by hexaosmium carbonyl clusters. Journal of Organometallic Chemistry 2009, 694, 834-839.
  21. Kien Voon Kong; Leong, W. K*.; Ng, S. P.; Nguyen, T. H.; Lim, Lina H. K. Osmium Carbonyl Clusters: A New Class of Apoptosis Inducing Agents. ChemMedChem. 2008, 3, 1269-1275.
  22. Kien Voon Kong; Chew, W.; Lim, Lina H. K.; Leong, W. K*. Imaging in the Mid-Infrared Using an Organometallic Carbonyl Tag. Bioconjugate Chemistry. 2007, 18, 1370-1374.

    Book Chapter

    1. Handbook of Nanosensors: Materials and Technological Applications: Chapter of "The plasmon enhanced nanosensor design and experimental schemes for biosensing and bioimaging" Springer 2023, Accepted and in production
    2. SERS Biosensing and Bioimaging: Design and Applications in Cancer Diagnostics. Singapore: Springer. Jun, 2017 

    Patent

    1. Surface enhanced raman spectroscopy (SERS) marker conjugates and methods of their preparation.
      (International Patent. WO 2013180652 A1)
    2. Surface enhanced raman spectroscopy (SERS) marker conjugates and methods of their preparation.
      (US patent. 20150126388)
    3. PHOTOACOUSTIC IMAGING CONTRAST AGENT COMPOSITION.
      (International Patent. WO/2015/038066)
    4. METHOD OF DETECTING ANALYTES HAVING A THIOL FUNCTIONAL GROUP.
      (International Patent. WO/2015/041607)
    5. PHOTOACOUSTIC IMAGING CONTRAST AGENT.
      (International Patent. WO/2015/088444)
    6. METHOD OF DETECTING HYDROGEN PEROXIDE
      (International Patent. WO/2015/038077)
    7. METHOD FOR DETECTING ANALYTE USING SURFACE ENHANCED RAMAN SPECTROSCOPY, BIOSENSOR, AND METHOD OF MANUFACTURING THEREOF
      (International Patent. WO/2014/137291)
    8. Surface enhanced raman spectroscopy (sers) marker conjugates and methods of their preparation.
      (China Patent. CN104507871A)
    9. Surface enhanced raman spectroscopy (sers) marker conjugates and methods of their preparation
      (European patent EP2855360A4)
    10. PHOTOACOUSTIC IMAGING CONTRAST AGENT COMPOSITION.
      (European patent EP3043829 A1)
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